The active substance in Zoloft
The active ingredient is Generic Sertraline, which is an antidepressant.
Generic Zoloft with Sertraline is available in the form of coated tablets.
Contraindications of Zoloft
Among them are:
- Lactation period,
- Problems in the field of neurology,
- Manic states,
- Seizures of epilepsy,
- Hepatic and/or renal failure,
- Age younger than 6 years,
- A sharp decrease in weight.
Dosing and administration of Zoloft
50 mg of Zoloft are to be taken 1 time per day, regardless of food intake. In the absence of an effect, a gradual (within a few weeks) dose increasing up to 200 mg/day (at 50 mg/week) is possible. Some clinicians recommend prescribing a dose of 25 mg/day for 1-2 days. The dosage depends on the disease. Panic disorders: the initial dose is 25 mg/day, followed by an increase to 50 mg of Sertraline per day for 1 week. In the case of prolonged maintenance therapy, the minimum effective dose is prescribed. Obsessive-compulsive syndrome:
- For patients 13-17 years old the first dose is 50 mg/day,
- For patients 6-12 years of age, the initial dose is 25 mg/day, followed by an increase to 50 mg/day in 1 week.
If the effect is insufficient, the dose can be increased stepwise by 50 mg/day to 200 mg/day, with an interval of not less than 1 week.
For elderly patients, the initial dose of Zoloft is 25 mg/day (morning or evening), followed by a gradual increase.
Pharmacological action of Zoloft
It is an antidepressant, a specific inhibitor of serotonin reuptake, enhances its effects, and has little effect on the re-uptake of such elements as Norepinephrine and Dopamine. In the therapeutic doses, the seizure of serotonin in human platelets is allowed.
Zoloft also inhibits the excitation of serotonin neurons in the seam region, which leads to an initial increase in activity, followed by a decrease in receptor activity. It:
- Does not cause drug dependence,
- Does not have psycho-stimulating, sedative, and cardio-toxic effect,
- Does not change psychomotor activity.
Due to selective inhibition of seizure of serotonin, it does not increase the activity of the sympathetic nervous system.
Unlike antidepressants in the treatment of depression or obsessive-compulsive syndrome, Zoloft doesn’t increase body weight.
The initial effect develops within 1 week, full – in 2-4 weeks.
Side effects of Zoloft
Sertraline in Zoloft can cause:
- Allergic reactions,
- Bleeding (including nasal),
- Dry mouth,
- Decreased appetite.
Rare side effects of Zoloft:
- Increased appetite (possibly as a consequence of eliminating depression),
- Unstable stool,
- Spasms in the stomach,
- Flatulence or pain,
- Weight loss,
- Movement disorders (extrapyramidal symptoms, gait alteration),
- Symptoms of depression,
- Impaired vision (including blurred vision),
- Violation of sexual function,
- Skin rash and itching.
Overdose of Zoloft
Special instructions when accepting Zoloft
- During the period of treatment, it is necessary to control strictly the behavior of patients in a state of depression.
- Zoloft is prescribed no earlier than 14 days after the withdrawal of inhibitors.
- Women of childbearing age during treatment should use adequate methods of contraception.
- During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities.
How to buy Zoloft?
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